UNIREN SPRAY 1% w/w (Topical non-steroidal anti-inflammatory)

COMPOSITION: Each 100 g contain: Diclofenac diethylammonium eq. to Diclofenac sodium 1 g (1% w/w) Each puff strokes approximately delivers: 0.14 mL or 1.33 mg of Diclofenac sodium 1 (about 440 puffs per bottle) MECHANISM OF ACTION: Pharmacology UNIREN SPRAY is an anti-inflammatory and analgesic preparation designed for external application. Pharmacokinetics After cutaneous application of 1.5 g of UNIREN SPRAY, a rapid onset of Diclofenac absorption can be observed leading to measurable plasma levels of about 1 ng/mL as early as 30 minutes and to maximum levels of about 3 ng/mL at about 24 hours after application. The achieved systemic concentrations of Diclofenac are about 50 times lower than those achieved following oral administration of equivalent amounts of Diclofenac. Systemic plasma levels are not supposed to contribute to the efficacy of UNIREN SPRAY. Diclofenac is extensively bound to plasma proteins (about 99%). INDICATION: For the local symptomatic relief of pain and inflammation in: - Trauma of tendons, ligaments muscles and joints, e.g. due to sprains, strains and bruises - Localized form of soft tissue rheumatism DOSAGE AND ADMINISTRATION: Apply 3-4 times a day PACK SIZE: Bottle of 60 mL Significantly better pain control than gel. Spray formulation attains higher tissue concentration faster than gel and emugel formulations and thereby can achieve its pain relief effect faster Useful for local symptomatic relief of mild to moderate pain and inflammatory No gastrointestinal irritation Improves mobility Rapidly relieves pain Effective and well-tolerated Non-greasy and non-staining formula